Enzymatic Degradation of Organophosphorus Pesticides and Nerve Agents by EC: 3.1.8.2
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F20%3A00556635" target="_blank" >RIV/60162694:G44__/20:00556635 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/20:10421396
Result on the web
<a href="https://www.mdpi.com/2073-4344/10/12/1365" target="_blank" >https://www.mdpi.com/2073-4344/10/12/1365</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/catal10121365" target="_blank" >10.3390/catal10121365</a>
Alternative languages
Result language
angličtina
Original language name
Enzymatic Degradation of Organophosphorus Pesticides and Nerve Agents by EC: 3.1.8.2
Original language description
The organophosphorus substances, including pesticides and nerve agents (NAs), represent highly toxic compounds. Standard decontamination procedures place a heavy burden on the environment. Given their continued utilization or existence, considerable efforts are being made to develop environmentally friendly methods of decontamination and medical countermeasures against their intoxication. Enzymes can offer both environmental and medical applications. One of the most promising enzymes cleaving organophosphorus compounds is the enzyme with enzyme commission number (EC): 3.1.8.2, called diisopropyl fluorophosphatase (DFPase) or organophosphorus acid anhydrolase from Loligo Vulgaris or Alteromonas sp. JD6.5, respectively. Structure, mechanisms of action and substrate profiles are described for both enzymes. Wild-type (WT) enzymes have a catalytic activity against organophosphorus compounds, including G-type nerve agents. Their stereochemical preference aims their activity towards less toxic enantiomers of the chiral phosphorus center found in most chemical warfare agents. Site-direct mutagenesis has systematically improved the active site of the enzyme. These efforts have resulted in the improvement of catalytic activity and have led to the identification of variants that are more effective at detoxifying both G-type and V-type nerve agents. Some of these variants have become part of commercially available decontamination mixtures.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/NV18-09-00181" target="_blank" >NV18-09-00181: Development of polyvalent decontamination mean</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Catalysts
ISSN
2073-4344
e-ISSN
2073-4344
Volume of the periodical
10
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
1365
UT code for WoS article
000602247100001
EID of the result in the Scopus database
2-s2.0-85096829167