In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9285" target="_blank" >RIV/00216208:11110/11:9285 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/11:00002430 RIV/00216208:11160/11:10100203
Result on the web
<a href="http://psych.lf1.cuni.cz/zf/publikace/d1025.pdf" target="_blank" >http://psych.lf1.cuni.cz/zf/publikace/d1025.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain
Original language description
Inhibition of the enzyme acetylcholinesterase (AChE) is the main mechanism both of therapeutic action of drugs for the treatment of Alzheimer?s disease and toxic action of organophosphorus compounds. Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents). Our results showed statistically significant Complex I inhibition by tacrine, other drugs did not affect the enzyme activity significantly.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F11%2F1907" target="_blank" >GAP303/11/1907: Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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