Pharmacological prophylaxis against nerve agent poisoning: experimental studies and practical implications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50004537" target="_blank" >RIV/62690094:18470/15:50004537 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/15:10320663
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00066-X" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-800159-2.00066-X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-800159-2.00066-X" target="_blank" >10.1016/B978-0-12-800159-2.00066-X</a>
Alternative languages
Result language
angličtina
Original language name
Pharmacological prophylaxis against nerve agent poisoning: experimental studies and practical implications
Original language description
Prophylaxis against intoxication with organophosphate (OP) nerve agents is based on various approaches. Protection of acetylcholinesterase (AChE), the target enzyme for toxic action of OP nerve agents, is a basic requirement for effective prophylaxis. This can be achieved by using reversible AChE inhibitors, preferably carbamates (CMs). AChE inhibited by CMs is resistant to the action of an OP nerve agent for a transient period. After spontaneous recovery of the activity, normal AChE serves as a sourceof the active enzyme. Detoxification is carried out by the administration of enzymes hydrolyzing the OPs or evaluating specific enzymes (cholinesterases). The OP nerve agent is bound to the exogenously administered enzyme, and thus the OP level in the organism is decreased ("scavenger" effect). The administration of enzymes such as AChE and butyrylcholinesterase (BuChE) as scavengers seems to be very promising, as the enzyme acts at the very beginning of the toxic action, and without int
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
KA - Militarism
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Handbook of toxicology of chemical warfare agents
ISBN
978-0-12-800159-2
Number of pages of the result
9
Pages from-to
979-987
Number of pages of the book
1184
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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