Organophosphorus degrading enzymes: Molecular basis and perspectives for enzymatic bioremediation of agrochemicals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F17%3A50014108" target="_blank" >RIV/62690094:18450/17:50014108 - isvavai.cz</a>

Result on the web

<a href="http://www.scielo.br/scielo.php?pid=S1413-70542017000500471&script=sci_arttext" target="_blank" >http://www.scielo.br/scielo.php?pid=S1413-70542017000500471&script=sci_arttext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1590/1413-70542017415000417" target="_blank" >10.1590/1413-70542017415000417</a>

Result language

angličtina

Original language name

Organophosphorus degrading enzymes: Molecular basis and perspectives for enzymatic bioremediation of agrochemicals

Original language description

Many organophosphorus compounds (OP) are used until today in agriculture as pesticides and, unfortunately, they are used as chemical warfare agents (or nerve agents) as well. Organophosphorus pesticides and nerve agents are extremely toxic molecules, since they act as Acetylcholinesterase (AChE) inhibitors. The most worrying effect of the exposure to these compounds is the acute cholinergic toxicity, which is the loss of muscle coordination. Once one is contaminated, the intoxication process begins through the binding of the OP in the active site of the AChE enzyme inactivating it. Current treatments for people exposed to low doses of OP can be performed with atropine, oximes and benzodiazepines. Important remediation processes involve the employment of bioremediation techniques using different degrading enzymes, such as the Phosphotriesterase from Agrobacterium radiobacter and SMP-30. Due to the high number of intoxications annually, it is crucial to search for more potent and effective treatment methods, and in this line, the techniques involving bioremediation seem to be quite promising for this purpose.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CIENCIA E AGROTECNOLOGIA

ISSN

1413-7054

e-ISSN

—

Volume of the periodical

41

Issue of the periodical within the volume

5

Country of publishing house

BR - BRAZIL

Number of pages

12

Pages from-to

471-482

UT code for WoS article

000416012500001

EID of the result in the Scopus database

2-s2.0-85032569608