Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG45__%2F24%3A00559074" target="_blank" >RIV/60162694:G45__/24:00559074 - isvavai.cz</a>

Result on the web

<a href="https://www.shd-pub.org.rs/index.php/JSCS/article/view/12165" target="_blank" >https://www.shd-pub.org.rs/index.php/JSCS/article/view/12165</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2298/JSC221207025R" target="_blank" >10.2298/JSC221207025R</a>

Result language

angličtina

Original language name

Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite

Original language description

The report describes the development of methods for rapid and simple identification of Adamsite in mobile laboratory conditions using a field gas chromatograph coupled with mass spectrometer. Adamsite is a chemical warfare agent with unique properties that cannot be analyzed without conversion to a volatile derivative. Derivatization procedures with 5 aliphatic thiols (ethanethiol, 1-propanethiol, 2-propanethiol, 1-butanethiol and 1-hexanethiol) were developed and compared. The retention characteristics of the derivatization products, peak characteristics and the formation of unwanted artifacts in the chromatograms were monitored. The influence of the reaction media and the time dependence of the reaction were also objects of interest. Other investigated parameters were the optimal reaction temperature and the volume of the derivatization agent. Mass spectra of newly created substances that are not yet included in the chemical weapons related databases were recorded. With optimal reagents (1-butanethiol and 1-hexanethiol), calibration procedures for analyte determination were subsequently developed, and the methods were verified during the Adamsite identification test in selected environmental and urban matrices.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10400 - Chemical sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Serbian Chemical Society

ISSN

0352-5139

e-ISSN

—

Volume of the periodical

88

Issue of the periodical within the volume

6

Country of publishing house

RS - THE REPUBLIC OF SERBIA

Number of pages

14

Pages from-to

639-652

UT code for WoS article

001015385100001

EID of the result in the Scopus database

2-s2.0-85164802012