Inheritance of malignant melanoma in the MeLiM strain of miniature pigs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F04%3A7286" target="_blank" >RIV/60460709:41210/04:7286 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/04:00108505

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inheritance of malignant melanoma in the MeLiM strain of miniature pigs

Original language description

Selective breeding of miniature pigs bearing cutaneus tumours resulted in the establishment of the MeLiM strain with malignant melanoma.The inheritance of melanoma was tested in a two-generation kindred comprising 456 progeny from 78 litters. Melanomas were recognisable visually as black-pigmented melanoma forms known in human melanoma, i.e. pigmented naevi, dysplastic naevi, superficial spreading melanoma and nodular malignant melanoma, were found in the MeLiM pigs. Because the occurence of nodular malignant melanoma segregated in all recorded litters we have included only this form in the genetic analysis. The tumours were nodular with exophytic growth over the skin surface. All showed similar histopathological features, vertical growh to muscle fascia and high metastatic activity. We hypothesize, on the basis of segregation ratios obtained from various mating types, that the mode of inheritance of nodular melanoma in the MeLim strain is probably controlled by three genes.

Czech name

Dědičnost maligního melanomu u populace MeLim miniaturních prasat

Czech description

Selective breeding of miniature pigs bearing cutaneus tumours resulted in the establishment of the MeLiM strain with malignant melanoma.The inheritance of melanoma was tested in a two-generation kindred comprising 456 progeny from 78 litters. Melanomas were recognisable visually as black-pigmented melanoma forms known in human melanoma, i.e. pigmented naevi, dysplastic naevi, superficial spreading melanoma and nodular malignant melanoma, were found in the MeLiM pigs. Because the occurence of nodular malignant melanoma segregated in all recorded litters we have included only this form in the genetic analysis. The tumours were nodular with exophytic growth over the skin surface. All showed similar histopathological features, vertical growh to muscle fascia and high metastatic activity. We hypothesize, on the basis of segregation ratios obtained from various mating types, that the mode of inheritance of nodular melanoma in the MeLim strain is probably controlled by three genes.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary Medicine - Czech

ISSN

0375-8427

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

12

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

453-459

UT code for WoS article

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EID of the result in the Scopus database

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