Immune Characterization of the Lewis Rats Inoculated with K2 Sarcoma Cell Line and Newly Derived R5-28 Malignant Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F05%3A14122" target="_blank" >RIV/60460709:41210/05:14122 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/05:00027346 RIV/00216208:11310/05:9299

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Immune Characterization of the Lewis Rats Inoculated with K2 Sarcoma Cell Line and Newly Derived R5-28 Malignant Cells

Original language description

Sarcoma is a relatively rare malignant disease with high mortality, bad prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22th25th day after inoculation (D = 2225), only 60%75% of R5-28-inoculated rats were affected by tumours. Thefrequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in both cases. All affected animals showed large splenomegaly. Apossible response of some immune system components to tumours was tested. No tumourinfiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers of

Czech name

Charakterizace imunitní odpovědi potkanů linie Lewis na inokulaci buněk sarkomové linie K2 a na nově odvozené maligní buňky R5-28

Czech description

Sarcoma is a relatively rare malignant disease with high mortality, bad prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22th25th day after inoculation (D = 2225), only 60%75% of R5-28-inoculated rats were affected by tumours. Thefrequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in both cases. All affected animals showed large splenomegaly. Apossible response of some immune system components to tumours was tested. No tumourinfiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers of

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GG - Zootechnics

OECD FORD branch

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Project

<a href="/en/project/GA524%2F04%2F0102" target="_blank" >GA524/04/0102: A study of immunological answer after tumour devitalization in different animal models</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica - Prague

ISSN

0015-5500

e-ISSN

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Volume of the periodical

51

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

159-165

UT code for WoS article

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EID of the result in the Scopus database

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