Immune Characterization of the Lewis Rats Inoculated with K2 Sarcoma Cell Line and Newly Derived R5-28 malignant cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F06%3A16358" target="_blank" >RIV/60460709:41210/06:16358 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Imunologická charakteristika potkanů kmene Lewis osídlených K2 sarkomovou buněčnou linií a nově vytvořenými R5-28 maligními buňkami

Original language description

Sarcoma is a relatively rare malignant disease with high mortality, but prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22nd 25th day after inoculation (D = 22-25), only 60%-75% of R5-28-inoculated rats were affected by tumours.The frequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in all cases. All affected animals showed large splenomegaly. A possible response of some immune system components to tumours was tested. Notumour infiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers

Czech name

Imunologická charakteristika potkanů kmene Lewis osídlených K2 sarkomovou buněčnou linií a nově vytvořenými R5-28 maligními buňkami

Czech description

Sarcoma is a relatively rare malignant disease with high mortality, but prognosis and response to conventional therapy. Two possible models of this disease were tested: the K2 rat sarcoma cell line, which was described previously, and the new rat R5-28 cell line derived from a spontaneously growing rat neoplasm with sarcoma morphology. While all rats inoculated with K2 cells developed tumours at 22nd 25th day after inoculation (D = 22-25), only 60%-75% of R5-28-inoculated rats were affected by tumours.The frequency and progress of the disease depended on the number of inoculated cells. No metastases were detected in all cases. All affected animals showed large splenomegaly. A possible response of some immune system components to tumours was tested. Notumour infiltrating lymphocytes were revealed in the tumour tissue. Anti-tumour antibodies were not found in tumour-bearing animal sera. Appropriate changes in peripheral blood lymphocyte subsets were explored. While the relative numbers

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GG - Zootechnics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica - Prague

ISSN

0015-5500

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

51

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

159-165

UT code for WoS article

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EID of the result in the Scopus database

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