Tumour Progression and Spontaneous Regression in the Lewis Rat Sarcoma Model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00453703" target="_blank" >RIV/67985904:_____/15:00453703 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/15:69854 RIV/00216208:11310/15:10321163 RIV/00216208:11120/15:43910510 RIV/00064173:_____/15:#0000458 RIV/00064211:_____/15:#0000445

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Tumour Progression and Spontaneous Regression in the Lewis Rat Sarcoma Model

Original language description

Spontaneous regression of tumours is a fascinating phenomenon rarely observed in oncological patients. We used a Lewis rat sarcoma model in which subcutaneous tumours developed after inoculation of the R5-28/clone C4 cells. Rats with tumour progression showed splenomegaly and anaemia. Tumour growth was associated with leucocytosis, granulocytosis, decrease in lymphocyte and CD161(+) population in peripheral blood and increase in serum MCP1 concentration. Animals with spontaneous regression of tumours initially showed an increase in white blood cells number and proportion of granulocytes. Between the 42nd and 49th day, however, values of these parameters dropped in correlation with reduction of tumour size. In spontaneously regressed tumours, vascularization was higher and on the contrary, progressive tumours had more necrotic areas with a high number of infiltrating granulocytes. In conclusion, progression and spontaneous regression of tumours in the Lewis rat sarcoma model is associated with distinct changes in populations of blood cells and immune cells which participate in these completely different processes of tumourigenesis.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/ED2.1.00%2F03.0124" target="_blank" >ED2.1.00/03.0124: ExAM Experimental Animal Models</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

12

Country of publishing house

GR - GREECE

Number of pages

11

Pages from-to

6539-6549

UT code for WoS article

000367447400025

EID of the result in the Scopus database

2-s2.0-84949463714