Immunohistochemical Evidence of the Involvement of Natural Killer (CD161(+)) Cells in Spontaneous Regression of Lewis Rat Sarcoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00503687" target="_blank" >RIV/67985904:_____/19:00503687 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/19:77995 RIV/00064211:_____/19:W0002048
Result on the web
<a href="http://iv.iiarjournals.org/content/33/1/47.full.pdf" target="_blank" >http://iv.iiarjournals.org/content/33/1/47.full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/invivo.11437" target="_blank" >10.21873/invivo.11437</a>

Result language
angličtina
Original language name
Immunohistochemical Evidence of the Involvement of Natural Killer (CD161(+)) Cells in Spontaneous Regression of Lewis Rat Sarcoma
Original language description
Background/Aim: Spontaneous regression (SR) of tumours is a rare phenomenon not yet fully understood. The aim of this study was to investigate immune cells infiltrating progressive and SR tumours in a Lewis rat sarcoma model. Materials and Methods: Rats were subcutaneously inoculated with rat sarcoma R5-28 (clone C4) cells. Developing tumours were obtained on day 42 and cryosections were immunohistochemically processed for detection of immune cells. Results: A high density of granulocytes was found in the necrotic areas of both progressive and SR tumours. CD4(+) cells and CD8(+) cells were rare and sparsely dispersed in the tumour tissue without clear difference between the two types of tumours. On the contrary, CD161(+) cells were abundant and evenly distributed in SR tumours, but these cells were very rare in progressive tumours. Conclusion: Based on the differences in number and distribution of the immune cell subpopulations, we believe that natural killer (CD161(+)) cells play a major role in the destruction of cancer cells during SR of tumours in this Lewis rat model.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
<a href="/en/project/LO1609" target="_blank" >LO1609: Models of the Serious Human Diseases: Traumatic Spinal Cord Injury, Huntington’s Disease, Melanoma and Infertility</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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