Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F14%3A65831" target="_blank" >RIV/60460709:41210/14:65831 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00438976 RIV/61388955:_____/14:00438976

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model

Original language description

The response of different strains of laboratory rats on both acute (via intraperitoneal injection) and chronic (via drinking water and/or diet) cadmium intoxication was investigated in the model study. Total Cd levels and metallothionein (MT) concentrations were determined in the liver of animals. The liver MT concentrations were determined by using adsorptive chronopotentiometry and modified Brdička reaction and were significantly correlated (r = 0.965) with the total liver Cd content. The Cd application resulted in increasing zinc liver contents confirming intensive MT synthesis in the rat liver. In the blood plasma, specific enzymatic activity of glutathione reductase (GR) and glutathione-S-transferase (GST) was determined suggesting increasing activity of GR with the amount of applied Cd, whereas ambiguous results have been found for the activity of GST. MT concentrations seemed to be more sensitive indicators of the Cd intoxication compared to the assessment of the specific enzyma

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Czech Journal of Animal Science

ISSN

1212-1819

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

12

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

548-556

UT code for WoS article

000346482200002

EID of the result in the Scopus database

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