In vitro immunomodulatory activity, cytotoxicity and chemistry of some central European polypores
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F16%3A70332" target="_blank" >RIV/60460709:41210/16:70332 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41340/16:70332 RIV/00216208:11160/16:10328802
Result on the web
<a href="http://dx.doi.org/10.3109/13880209.2016.1156708" target="_blank" >http://dx.doi.org/10.3109/13880209.2016.1156708</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13880209.2016.1156708" target="_blank" >10.3109/13880209.2016.1156708</a>
Alternative languages
Result language
angličtina
Original language name
In vitro immunomodulatory activity, cytotoxicity and chemistry of some central European polypores
Original language description
Context Some mushrooms of the order Polyporales are known for their immunomodulatory actions. Objective The objective of this study is to evaluate the in vitro phagocytic and cytotoxic effects of extracts from polyporales native to Central Europe. Materials and methods The effects of ethanol extracts from 27 polypore species on opsonized zymosan-induced phagocytosis of isolated human neutrophils were tested by a chemiluminescence method. Colon epithelial cell lines, Caco-2 and HT-29, were used for cytotoxicity assays, and extracts were chemically characterized in terms of total phenolic and beta-glucan content. Results We observed phagocytosis or respiratory burst enhancing activity in 17 extracts, of which five species, namely Aurantiporus fissilis, Trametes gibbosa, Piptoporus betulinus, Neolentinus lepideus, Polyporus squamosus, significantly increased phagocytosis in granulocytes. Some extracts showed cytotoxic activity, with higher cytotoxicity in Caco-2 than in HT-29 cells. Pycnoporus cinnabari
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/LD14070" target="_blank" >LD14070: Adhesive properities of probiotics to the intestinal epithelium</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Biology
ISSN
1388-0209
e-ISSN
—
Volume of the periodical
54
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
2369-2376
UT code for WoS article
000386041900001
EID of the result in the Scopus database
—