Tissue Rebuilding During Spontaneous Regression of Melanoma in the Melanoma-bearing Libechov Minipig
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A76917" target="_blank" >RIV/60460709:41210/18:76917 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/18:00499609 RIV/00216208:11310/18:10383040 RIV/00216208:11120/18:43916935
Result on the web
<a href="http://dx.doi.org/10.21873/anticanres.12767" target="_blank" >http://dx.doi.org/10.21873/anticanres.12767</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.12767" target="_blank" >10.21873/anticanres.12767</a>
Alternative languages
Result language
angličtina
Original language name
Tissue Rebuilding During Spontaneous Regression of Melanoma in the Melanoma-bearing Libechov Minipig
Original language description
Background/Aim: Melanoma is a cancer disease with increasing incidence in the Caucasian population. It is often accompanied by spontaneous regression (SR), probably due to high immunogenicity. Understanding of this phenomenon could allow its induction in clinical practice, but detailed study in humans is impossible for ethical reasons. The aim of this study was to determine the role of fibronectin, tenascin C, and MMP-2 in the process of SR. Materials and Methods: Time-lapse study of SR was performed in the MeLiM (Melanoma-bearing Libechov Minipig) model. Skin melanomas were taken from 3 weeks to 8 months of age and immunohistochemically processed for fibronectin, tenascin C and matrix metalloproteinase-2 (MMP-2). Results: Expression of all studied proteins increased up to the 10th week of age. Two structurally different areas were distinguishable from the 3rd month of age. MPP-2 expression predominated in areas with melanoma cells, whereas fibronectin and tenascin-C prevailed in the forming fibrous
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANTICANCER RESEARCH
ISSN
0250-7005
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
8
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
4629-4636
UT code for WoS article
000449948300027
EID of the result in the Scopus database
2-s2.0-85050801728