In vitro synergistic effect of Hibiscus sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical isolates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41330%2F16%3A69212" target="_blank" >RIV/60460709:41330/16:69212 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/16:43873467
Result on the web
<a href="http://dx.doi.org/10.3109/13880209.2015.1126618" target="_blank" >http://dx.doi.org/10.3109/13880209.2015.1126618</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13880209.2015.1126618" target="_blank" >10.3109/13880209.2015.1126618</a>
Alternative languages
Result language
angličtina
Original language name
In vitro synergistic effect of Hibiscus sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical isolates
Original language description
Context: The increasing problem of drug-resistant strains has led to the failure of current treatment regimens of Helicobacter pylori (HP) infection. Recently, a new treatment strategy has been developed to overcome the problem by using natural products in combination with antibiotics to enhance the treatment efficacy. Objective: The antimicrobial combinatory effect of the aqueous extract of Hibiscus sabdariffa L. (Malvaceae) (AEHS) with antibiotics (clarithromycin, CLA; amoxicillin, AMX; metronidazole, MTZ) has been evaluated in vitro against HP strains. Materials and methods: Hibiscus calyces (35 g) were brewed in 250 mL of boiled water for 30 min, and minimum inhibitory concentrations (MICs) were determined by agar dilution method. The checkerboard assay was used to evaluate the antimicrobial combinatory effect according to the sum of fractional inhibitory concentration (?FIC) indices. Results: In this study, AEHS exerted remarkable bacteriostatic effect against all HP strains tested with
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Biology
ISSN
1388-0209
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1736-1740
UT code for WoS article
000382572400027
EID of the result in the Scopus database
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