Determination of anti-staphylococcal activity of thymoquinone in combinations with antibiotics by checkerboard method using EVA capmatTM as a vapor barrier

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41340%2F16%3A67295" target="_blank" >RIV/60460709:41340/16:67295 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/17:73968 RIV/60460709:41340/17:73968 RIV/75010330:_____/17:00011772

Result on the web

<a href="http://dx.doi.org/10.1016/j.arabjc.2015.04.021" target="_blank" >http://dx.doi.org/10.1016/j.arabjc.2015.04.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.arabjc.2015.04.021" target="_blank" >10.1016/j.arabjc.2015.04.021</a>

Result language

angličtina

Original language name

Determination of anti-staphylococcal activity of thymoquinone in combinations with antibiotics by checkerboard method using EVA capmatTM as a vapor barrier

Original language description

Thymoquinone (Tq) has been reported to potentiate the in vitro growth-inhibitory activity of some antibiotics especially against Staphylococcus aureus. However, it has been shown that Tq vapors can affect the results of susceptibility testing by standard broth microdilution method. Therefore, we made a comparative experiment with and without ethylene vinyl acetate cap mats (EVA capmatTM) on microplates. The results showed significant differences in the minimum inhibitory concentration values and proved this capmat as an effective vapor barrier. Therefore further experiments focused on the in vitro anti-staphylococcal combinatory effect of Tq with oxacillin, penicillin, and tetracycline against various S. aureus strains have been performed by checkerboard method using EVA capmatTM. The combined effect was evaluated according to the sum of fractional inhibitory concentrations (?FIC). Synergy was obtained for combination with oxacillin against 3 (?FIC 0,263-0,450), with penicillin against 1 (?FIC 0,466)

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GM - Food industry

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0040" target="_blank" >EE2.3.30.0040: Development of research teams at Czech University of Life Sciences Prague for enhancement of educational activities in departments outside Prague</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Arabian Journal of Chemistry

ISSN

1878-5352

e-ISSN

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Volume of the periodical

N

Issue of the periodical within the volume

N

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

1-6

UT code for WoS article

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EID of the result in the Scopus database

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