Fluorinated epoxides 6. Chemoselectivity in the preparation of 2-[(heptafluoroispropyl)methyl]oxirane from iodohydrin precursors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F03%3A00007918" target="_blank" >RIV/60461373:22310/03:00007918 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fluorinated epoxides 6. Chemoselectivity in the preparation of 2-[(heptafluoroispropyl)methyl]oxirane from iodohydrin precursors
Original language description
Fluorinated iodoacetate (CF3)2CFCH2CHICH2OAc (1) (prepared by radical addition of perfluoro-isopropyl iodide to allyl acetate) and fluorinated iodohydrin (CF3)2CFCH2CHICH2OH (2) (prepared from 1) were converted to the corresponding perfluoroalkylated oxirane (CF3)2CFCH2CH(-O-)CH2 (3) in the yield of 62%. The chemo-selectivity of the oxirane formation appeared to be strongly dependent on the starting compounds 1 or 2 and on solvent used. Byproducts (CF3)2CFCH=CHCH2OH (4) and (CF3)2CFCH=CHCH2OAc (5) can form a major part of the products in the formation of epoxide 3.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA203%2F01%2F1311" target="_blank" >GA203/01/1311: New generation of compounds for blood substitutes and other medicinal applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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