Syntheses of O6-Alkyl- and Arylguanine Derivatives, Nucleobase Adducts Derived from Styrene 7,8- and 3,4-oxides.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F06%3A00016589" target="_blank" >RIV/60461373:22310/06:00016589 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Syntheses of O6-Alkyl- and Arylguanine Derivatives, Nucleobase Adducts Derived from Styrene 7,8- and 3,4-oxides.
Original language description
A series of O6-alkyl and O6-arylguanine derivatives which may be formed in vivo after exposure to styrene has been prepared by reaction of 6-(4-aza-1-azoniabicyclo2.2.2octyl)-purine with alkoxides and aryloxides, respectively. Monoprotected diols, 2-allyloxy- or 2-benzyloxy-1-phenylethanol and 2-allyloxy- or 2-benzyloxy-2-phenylethanol were used as synthetic equivalents of styrene 7,8-oxide. 4-Vinylphenol, 2-(4-hydroxyphenyl)ethanol and 4-hydroxyphenylacetic acid were used as synthetic equivalents of arenoxide metabolites of styrene, i.e., styrene 3,4-oxide, 4-(2-hydroxyethyl)benzene 1,2-oxide and 4-carboxymethylbenzene 1,2-oxide, respectively.
Czech name
Sntéza 06-alkyl- a arylderivátů guaninu, nukleobasových aduktů odvozených od styrenu
Czech description
Byl vyvinut syntetický postup pro přípravu dvou alkyl- a tří arylderivátů guaninu jako DNA aduktů odvozených od styrenu. Látky jsou určeny pro vývoj diagnostických metod poškození DNA styrenem.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA310%2F03%2F0437" target="_blank" >GA310/03/0437: New aspects in understanding styrene genotoxicity: the role of DNA repair,new reactive metabolites and secondary oxidative stress</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Organic Chemistry
ISSN
1434-193X
e-ISSN
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Volume of the periodical
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Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
507-515
UT code for WoS article
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EID of the result in the Scopus database
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