New Layered Double Hydroxides/Phospholipid Bilayer Hybrid Material with Strong Potential for Sustained Drug Delivery System.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F09%3A00021442" target="_blank" >RIV/60461373:22310/09:00021442 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New Layered Double Hydroxides/Phospholipid Bilayer Hybrid Material with Strong Potential for Sustained Drug Delivery System.

Original language description

A new supra-organized hybrid material obtained in aq. medium via anionic exchange of self-assembled unilamellar anionic liposomes with the nitrate ions present in the interlayers of layered double hydroxides (LDH) is fully characterized. This material presents original properties linked to the simultaneous presence of a phospholipid bilayer derived from liposomes, still used as vectors for lipophilic drugs, and LDH, which protects the bilayer and brings about a pH sensitivity. The exchange rate is controlled via the added amt. of liposomes. TGA, XRD, and TEM confirm the organization of the entrapped phospholipids as a bilayer. The presence of the latter allows the material to load lipophilic and neutral drugs, which represent the largest fraction of those newly synthesized. Furthermore, in physiol. conditions, preliminary tests show a sustained release of phospholipids (1.5% for 7 days and 6% for 14 days), whereas a fluorescent lipophilic drug-mimic reveals the reorganization of the ph

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry of Materials

ISSN

0897-4756

e-ISSN

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Volume of the periodical

2009

Issue of the periodical within the volume

21

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

000268138200024

EID of the result in the Scopus database

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