Impact of lipid composition and photosensitizer hydrophobicity on the efficiency of light-triggered liposomal release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73584557" target="_blank" >RIV/61989592:15310/17:73584557 - isvavai.cz</a>
Result on the web
<a href="http://pubs.rsc.org/en/content/articlehtml/2017/cp/c7cp00983f" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2017/cp/c7cp00983f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7cp00983f" target="_blank" >10.1039/c7cp00983f</a>
Alternative languages
Result language
angličtina
Original language name
Impact of lipid composition and photosensitizer hydrophobicity on the efficiency of light-triggered liposomal release
Original language description
Photo-triggerable liposomes are considered nowadays as promising drug delivery devices due to their potential to release encapsulated drugs in a spatial and temporal manner. In this work, we have investigated the photopermeation efficiency of three photosensitizers (PSs), namely verteporfin, pheophorbide a and m-THPP when incorporated into liposomes with well-defined lipid compositions (SOPC, DOPC or SLPC). By changing the nature of phospholipids and PSs, the illumination of the studied systems was shown to significantly alter their lipid bilayer properties via the formation of lipid peroxides. The system efficiency depends on the PS/phospholipid association, and the ability of the PS to peroxidize acyl chains. Our results demonstrated the possible use of these three clinically approved (or under investigation) PSs as potential candidates for photo-triggerable liposome conception.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physical Chemistry Chemical Physics
ISSN
1463-9076
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
11460-11473
UT code for WoS article
000401022300049
EID of the result in the Scopus database
2-s2.0-85024481341