New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F10%3A00022959" target="_blank" >RIV/60461373:22310/10:00022959 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

New urinary matabolites formed from ring-oxidized metabolic intermediates of styrene

Original language description

The urine from mice exposed to styrene vapors (600 and 1200 mg/m3, 6h) was analyzed for ring-oxidized metabolites of styrene. To facilitate the identification of metabolites in urine, following potential metabolites were prepared: 2-, 3-, and 4-vinylphenol (2-, 3- and 4-VP), 4-vinylpyrocatechol, and 2-, 3- and 4-vinylphenylmercapturic acid (2-, 3- and 4-VPMA). For the analysis of vinylphenols beta-glucuronidase-treated urine was extracted and derivatized with acetanhydride/ triethylamine before the injection into GC/MS. Three isomers, 2-, 3- and 4-VP, were found in the exposed urine using authentic standards. Additionally, three novel minor urinary metabolites, arylmercapturic acids 2-, 3- and 4-VPMA, were identified by LC-ESI-MS2 by comparison with authentic standards. Excretion of the most abundant isomer, 4-VPMA, amounted to 535 +/- 47 nmol/kg and 984 +/- 78 nmol/kg, representing approx. 0.047 and 0.043 % of the absorbed dose for the exposure levels of 600 and 1200 mg/m3, respective

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

<a href="/en/project/2B08051" target="_blank" >2B08051: New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chem. Res. Toxicol.

ISSN

0893-228X

e-ISSN

—

Volume of the periodical

23

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

—

UT code for WoS article

000273618500029

EID of the result in the Scopus database

—