Vinylphenylmercapturic acids in human urine as biomarkers of styrene ring oxidation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F12%3A00009784" target="_blank" >RIV/75010330:_____/12:00009784 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Vinylphenylmercapturic acids in human urine as biomarkers of styrene ring oxidation

Original language description

New metabolites of styrene, three isomeric vinylphenylmercapturic acids (2-, 3-, and 4-VPMA), were recently identified by LC-ESI-MS in the urine of mice. In this study, 4-VPMA together with traces of 2- and 3-VPMA were found also in the urine of hand-lamination workers, which were exposed to styrene vapours at concentrations ranging from 23 to 244 mg/m(3). Despite very low metabolic yield, formation of VPMAs clearly indicates occurrence and extent of styrene ring oxidation considered to be a toxicologically relevant metabolic pathway.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/2B08051" target="_blank" >2B08051: New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology letters

ISSN

0378-4274

e-ISSN

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Volume of the periodical

213

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

260-265

UT code for WoS article

000308769700016

EID of the result in the Scopus database

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