HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43891933" target="_blank" >RIV/60461373:22310/11:43891933 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/00032719.2010.546027" target="_blank" >http://dx.doi.org/10.1080/00032719.2010.546027</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00032719.2010.546027" target="_blank" >10.1080/00032719.2010.546027</a>

Result language
angličtina
Original language name
HPLC Method for the Determination of the Purity of K[Pt(NH3)Cl3], a Precursor of the Platinum Complexes with Cytostatic Activity
Original language description
K[Pt(NH3)Cl3], a valuable precursor for the prepn. of platinum complexes with cytostatic activity, e.g. satraplatin, picoplatin, LA-12, and cycloplatam, is currently prepd. from cis-[Pt(NH3)2Cl2] or K2[PtCl4] and these are the usual impurities in the final product. A simple, selective, and sensitive HPLC-UV anal. method for the detn. of the purity of K[Pt(NH3)Cl3] and the quantification of the impurities was developed and validated. The platinum complexes present in the final product were sepd. on a strong base ion exchange column by the gradient elution with detection at 213 nm. Intra-assay precisions for the platinum complexes resp. to their ions ([PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2]) were between 0.1% and 2.0% (relative std. deviation); intermediate precisions were between 1.4% and 2.0% and accuracies were between 98.6% and 101.4%. Limits of detection of [PtCl4]2-, [Pt(NH3)Cl3]-, and cis-[Pt(NH3)2Cl2] were 6 mýg/mL-1, 13 mg/mL-1, and 5 mýg/mL-1 resp., limits of quantifica
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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