Increasing dissolution of trospium chloride by co-crystallization with urea

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897874" target="_blank" >RIV/60461373:22310/14:43897874 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jcrysgro.2014.04.018" target="_blank" >http://dx.doi.org/10.1016/j.jcrysgro.2014.04.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcrysgro.2014.04.018" target="_blank" >10.1016/j.jcrysgro.2014.04.018</a>

Result language
angličtina
Original language name
Increasing dissolution of trospium chloride by co-crystallization with urea
Original language description
The search for various solid forms of an active pharmaceutical ingredient (API) is an important step in drug development. Our aim was to prepare co-crystals of trospium chloride, an anticholinergic drug used for the treatment of incontinence, and to investigate if they have advantageous properties for drug formulation. Phase identification was done by powder X-ray diffraction and single-crystal X-ray diffraction. The chemical composition was verified by solution NMR and the dissolution rate of the prepared phases was studied by IDR (intrinsic dissolution rate). For further analysis of phase stability and transitions, combined thermal analysis and temperature-resolved X-ray powder diffraction were used. Urea was selected as a co-crystallization partner.Trospium chloride urea (1:1) co-crystal was prepared by a solvent evaporation. from single-crystal data, the co-crystal structure was solved in a space group P2(1)/c and compared to previously published structures of trospium chloride. I
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GA14-03636S" target="_blank" >GA14-03636S: Preparation and characterization of advanced multicomponent pharmaceutical solids with targeted physicochemical properties</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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