Trospium chloride: Unusual example of polymorphism based on structure disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F13%3A00425014" target="_blank" >RIV/68378271:_____/13:00425014 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/13:43895358
Result on the web
<a href="http://dx.doi.org/10.1021/cg4007394" target="_blank" >http://dx.doi.org/10.1021/cg4007394</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/cg4007394" target="_blank" >10.1021/cg4007394</a>
Alternative languages
Result language
angličtina
Original language name
Trospium chloride: Unusual example of polymorphism based on structure disorder
Original language description
The characterization of the solid state properties of an active pharmaceutical ingredient is a necessary step in drug development. One such API is trospium chloride, an anticholinergic drug used to treat incontinence and overactive bladder syndrome. Onecrystal form is known but, from the crystallographic point of view, has only been described by the X-ray powder diffraction pattern. Because, to the best of our knowledge, no crystal structures of trospium chloride have been published, we decided to prepare and describe different crystal forms. Using single-crystal X-ray diffraction, the structure s of two new polymorphs and of one unstable solvate were solved. All forms were obtained from ethanol mother liquor. Both polymorphs exhibited a significant pseudosymmetrical disorder. The polymorphs were highly similar but were distinguished by their symmetry and the resulting single-crystal diffraction behavior.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Crystal Growth & Design
ISSN
1528-7483
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
5193-5203
UT code for WoS article
000328100400008
EID of the result in the Scopus database
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