Effect of lubricants on disintegration stability of paracetamol-caffeine-phenylephrine tablets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43902911" target="_blank" >RIV/60461373:22310/16:43902911 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of lubricants on disintegration stability of paracetamol-caffeine-phenylephrine tablets
Original language description
The negative changes in the physical properties of tablets made of multicomponent mixtures containing paracetamol, caffeine, and phenylephrine hydrochloride as the active pharmaceutical ingredients are examined. The work focuses mainly on discovering the possible cause of the prolonged disintegration of tablets that increases with the time elapsed since their compression. The properties of the mixture components that could be responsible for affecting the tablet disintegration were investigated. The physical and chemical properties of the individual mixture components, their eutectic phases, crystalline and amorphous forms and stability were studied. The main object of investigation was stearic acid, a substance with a very low melting point and interesting crystalline variability. It was shown, that the unstable disintegrating properties of tablets were caused by the interactions between Stearic acid 50 and Collidone 25. The interactions between these two substances occur both during compaction and during prolonged storage of mixtures forming a glass phase. Several solutions were proposed to avoid the problem of the unstable disintegration of tablets.
Czech name
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Czech description
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS of the 4th International Conference on Chemical Technology
ISBN
978-80-86238-94-4
ISSN
2336-811X
e-ISSN
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Number of pages
6
Pages from-to
511-516
Publisher name
Česká společnost průmyslové chemie (ČSPCH)
Place of publication
Praha
Event location
Mikulov
Event date
Apr 25, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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