Sodium Aspirin Salts: Crystallization and Characterization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916878" target="_blank" >RIV/60461373:22310/18:43916878 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/18:43916878
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.cgd.8b00718" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.cgd.8b00718</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.cgd.8b00718" target="_blank" >10.1021/acs.cgd.8b00718</a>

Result language
angličtina
Original language name
Sodium Aspirin Salts: Crystallization and Characterization
Original language description
Acetylsalicylic acid (trade name aspirin) is a well-known drug with antipyretic and analgesic effects. Mixtures that benefit from better solubility of its sodium salt have been sold for almost 90 years. Currently, several drug products are available with sodium aspirin as their active ingredient, but, until now, its crystal structure remained unknown. We have investigated the multicomponent system of sodium acetylsalicylate with the following results: an anhydrate and a dihydrate of a 1:1 salt were identified together with a hemihydrate of a 2:1 salt. Crystal structures of all forms were solved by single-crystal X-ray diffraction. The structural changes upon desolvation were studied by simultaneous thermogravimetric/differential scanning calorimetry supported by X-ray powder diffraction. The crystal structures were compared to those of all up-to-date published crystal structures of aspirin salts. Both of the hydrated sodium salts belong to the same isostructural family, while the anhydrate crystallizes with a unique packing of the acetylsalicylate anions.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20401 - Chemical engineering (plants, products)

Project
<a href="/en/project/GA16-10035S" target="_blank" >GA16-10035S: Preparation of pharmaceutical co-crystals and their structural characterization by combination of electron single-crystal and x-ray powder diffraction</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)