Micro/nanomachines: what is needed for them to become a real force in cancer therapy?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43918526" target="_blank" >RIV/60461373:22310/19:43918526 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2019/nr/c8nr08022d" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2019/nr/c8nr08022d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8nr08022d" target="_blank" >10.1039/c8nr08022d</a>
Alternative languages
Result language
angličtina
Original language name
Micro/nanomachines: what is needed for them to become a real force in cancer therapy?
Original language description
Conventional drug delivery systems face several issues in medical applications, such as cyto/genotoxicity and off-targeting. These issues are particularly significant for cancer therapeutics because many of the currently used systems are toxic in their free form. Self-propelled autonomous micro/nanomachines offer promising alternative drug delivery systems based on high cargo loading, fast autonomous movement, precise targeting and the on-demand release of therapeutics in vivo. With this unique set of properties, it is not surprising that they are receiving considerable research attention. However, much less is reported about the drawbacks that hinder their systemic in vivo application. In this review, a biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems reported to date. Advantages along with present issues are highlighted and recommendations which need to be considered to develop an effective biocompatible micro/nanomotor-based delivery system for cancer therapy are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale
ISSN
2040-3364
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
6519-6532
UT code for WoS article
000464454400052
EID of the result in the Scopus database
2-s2.0-85064129502