Prediction of drug-carrier compatibility - Application of inverse gas chromatography

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43918643" target="_blank" >RIV/60461373:22310/19:43918643 - isvavai.cz</a>
Result on the web
<a href="https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf" target="_blank" >https://www.icct.cz/AngiologyKlon-ICCT/media/system/2019/ICCT-2019-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Prediction of drug-carrier compatibility - Application of inverse gas chromatography
Original language description
Most properties of final solid dosage forms, such as tablets, capsules or granules, are highly dependent on chosen excipients, especially on the interactions between their particles and those of active substance affecting the stability or content uniformity of the final product. Since many phenomena initiate at the particle surfaces, surface properties are one of the critical parameters known to influence formulation performance. Especially surface energy can project into several unit operations. Moreover, surface properties can be changed by these pre-treatment operations, primarily mixing or milling. The work was focused on the change in surface energy as a consequence of different mixing duration. Inverse gas chromatography was used to determine any changes in surface energy of levocetirizine dihydrochloride which was mixed with Kollidon® 12 PF or Kollidon® VA 64 in a weight ratio of 1:1. Furthermore, the energy balance of surface energy was employed to assess whether the components form agglomerates.
Czech name
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Czech description
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Project
<a href="/en/project/LO1613" target="_blank" >LO1613: Future materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 7th International Conference on Chemical Technology
ISBN
978-80-88307-00-6
ISSN
2336-811X
e-ISSN
2336-8128
Number of pages
5
Pages from-to
264-268
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Mikulov
Event date
Apr 15, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000515696600048

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