Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43920709" target="_blank" >RIV/60461373:22310/20:43920709 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/20:43920709 RIV/60461373:22340/20:43920709 RIV/60461373:22810/20:43920709 RIV/00023752:_____/21:43920439 and 2 more

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.2950" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.2950</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/dta.2950" target="_blank" >10.1002/dta.2950</a>

Result language

angličtina

Original language name

Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis

Original language description

Psilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin are tryptamines structurally similar to the neurotransmitter serotonin. Psilocybin and its pharmacologically active metabolite psilocin in particular are known for their psychoactive effects. These substances typically occur in most species of the genus Psilocybe (Fungi, Strophariaceae). Even the sclerotia of some of these fungi known as &quot;magic truffles&quot; are of growing interest in microdosing due to them improving cognitive function studies. In addition to microdosing studies, psilocybin has also been applied in clinical studies, but only its pure form has been administrated so far. Moreover, the determination of tryptamine alkaloids is used in forensic analysis. In this study, freshly cultivated fruit bodies of Psilocybe cubensis were used for monitoring stability (including storage and processing conditions of fruiting bodies). Furthermore, mycelium and the individual parts of the fruiting bodies (caps, stipes, and basidiospores) were also examined. The concentration of tryptamines in final extracts was analyzed using ultra-high-performance liquid chromatography coupled with mass spectrometry. No tryptamines were detected in the basidiospores, and only psilocin was present at 0.47 wt.% in the mycelium. The stipes contained approximately half the amount of tryptamine alkaloids (0.52 wt.%) than the caps (1.03 wt.%); however, these results were not statistically significant, as the concentration of tryptamines in individual fruiting bodies is highly variable. The storage conditions showed that the highest degradation of tryptamines was seen in fresh mushrooms stored at -80 degrees C, and the lowest decay was seen in dried biomass stored in the dark at room temperature.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/VI20172020056" target="_blank" >VI20172020056: New synthetics drugs - complex interdisciplinary research centre</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Testing and Analysis

ISSN

1942-7603

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

439-446

UT code for WoS article

000585171500001

EID of the result in the Scopus database

2-s2.0-85096679307