ASGPR and DC-SIGN: C-Type Lectin Receptors with a Promising Potential for Medicinal Chemistry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922169" target="_blank" >RIV/60461373:22310/21:43922169 - isvavai.cz</a>
Result on the web
<a href="http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3803" target="_blank" >http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3803</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
čeština
Original language name
Asgpr and dc-sign: C-type lectin receptors with a promising potential for medicinal chemistry [Asgpr a dc-sign: C-lektinové receptory se slibným potenciálem v medicinální chemii]
Original language description
Lectins are carbohydrate-binding proteins which are involved in plethora of vital processes such as cellular communication, cell migration and cell recognition. Many lectins play an important role in pathogen recognition and initiation of the immune response. Many of these receptors are uniquely expressed on defined cell subsets, which al-lows for specific targeting of these cells in the complex biological environment. This review highlights the rele-vance and main obstacles in using lectins as drug targets and discusses in detail the progress that has been made in targeting hepatocytes through the asialoglycoprotein receptor and dendritic cells through the DC-SIGN receptor. © 2021, Czech Society of Chemical Engineering. All rights reserved.
Czech name
Asgpr and dc-sign: C-type lectin receptors with a promising potential for medicinal chemistry [Asgpr a dc-sign: C-lektinové receptory se slibným potenciálem v medicinální chemii]
Czech description
Lectins are carbohydrate-binding proteins which are involved in plethora of vital processes such as cellular communication, cell migration and cell recognition. Many lectins play an important role in pathogen recognition and initiation of the immune response. Many of these receptors are uniquely expressed on defined cell subsets, which al-lows for specific targeting of these cells in the complex biological environment. This review highlights the rele-vance and main obstacles in using lectins as drug targets and discusses in detail the progress that has been made in targeting hepatocytes through the asialoglycoprotein receptor and dendritic cells through the DC-SIGN receptor. © 2021, Czech Society of Chemical Engineering. All rights reserved.
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemické listy
ISSN
0009-2770
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
126-133
UT code for WoS article
000627121000002
EID of the result in the Scopus database
2-s2.0-85102919213