The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F24%3A43931421" target="_blank" >RIV/60461373:22310/24:43931421 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/ics.12972" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/ics.12972</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ics.12972" target="_blank" >10.1111/ics.12972</a>

Result language

angličtina

Original language name

The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications

Original language description

Ceramides are a family of lipids constituted by a sphingoid base and a fatty acid. In the skin, they are mainly present in the stratum corneum where, with cholesterol and free fatty acids, they constitute the inter-corneocyte lipids. With the other lipid groups, they play a key role in the formation of dense lamellar structures between adjacent corneocytes, collectively ensuring the vital efficient barrier to water evaporation and protection from foreign agents´ penetration. Changes in ceramide level and relative composition, with potential impairment of lipid arrangement, have been evidenced in different skin conditions and skin diseases. Therefore, use of suitably formulated ceramides has been proposed for topical treatment to help re-structure damaged lipid arrangement and repair impaired skin barrier function. Nonetheless, the formulation of ceramides in products necessitates specific processes such as heating to high temperature before their introduction in the final formula. In this review on the structure, the role and the potential of ceramides for skincare, we point out the necessity of rigorous process when formulating ceramides into the final product. We demonstrate the counterproductive effects of undissolved ceramides on skin barrier repair capacity of the formulas, when assessed in different in vitro models of disrupted skin barrier. © 2024 Evonik Operations GmbH and The Author(s). International Journal of Cosmetic Science published by John Wiley &amp; Sons Ltd on behalf of Society of Cosmetic Scientists and Societe Francaise de Cosmetologie.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

ISSN

0142-5463

e-ISSN

—

Volume of the periodical

46

Issue of the periodical within the volume

4

Country of publishing house

ZA - SOUTH AFRICA

Number of pages

18

Pages from-to

526-543

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85200668381