High-performance enantioselective ion-exchange mixed matrix membranes based on PVDF and EVOH polymers with cinchona-derived chiral silica particles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43931790" target="_blank" >RIV/60461373:22310/25:43931790 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/25:43931790

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0376738825006891?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0376738825006891?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.memsci.2025.124376" target="_blank" >10.1016/j.memsci.2025.124376</a>

Result language

angličtina

Original language name

High-performance enantioselective ion-exchange mixed matrix membranes based on PVDF and EVOH polymers with cinchona-derived chiral silica particles

Original language description

Separation of racemic mixtures is pivotal and remains a challenging task since enantiomers exhibit identical physicochemical properties in achiral environments. Enantioselective membranes gain attention for their potential to achieve efficient and scalable chiral separation, offering a cost-effective and environmentally friendly alternative to traditional methods. Here, we present an innovative enantioselective ion-exchange mixed matrix membrane for the separation of racemic acids, involving quinidine-modified 5 μm silica particles dispersed in poly(ethylene-co-vinyl alcohol) (EVOH) or poly(vinylidene fluoride) (PVDF) matrices. The separation follows a sorption-driven mechanism based on the retarded transport model, requiring periodic regeneration using methanolic ammonium acetate solution. Optimal separation conditions for N-(3,5-dinitrobenzoyl)-leucine enantiomers were found at low ionic strength with a methanol, acetic acid, and ammonium acetate solvent system. Both PVDF-based membranes, prepared via non-solvent-induced phase separation (NIPS) with a high packing ratio of 1.2:1 (particle to polymer), and EVOH-based membranes with 1:1 ratio, prepared via combined vapour-induced phase separation (VIPS) and solvent-evaporation at 50 % relative humidity, achieved ≥98 % enantiomeric excess (ee) after five separation stages. Fluxes averaged on (1513 ± 255) mg/m2/h (PVDF) and (1190 ± 139) mg/m2/h (EVOH) at 1 mg/mL feed concentration with ∼5 % stage-over-stage recoveries. Pressure-driven enantioseparation using PVDF membranes required ∼20 stages to achieve &gt;90 % ee but provided ∼49 % recovery per stage. Leveraging the proven long-lasting performance of chromatographic enantioselective silica, the developed membranes enable scalable semi-continuous separation of acidic racemates. Attractively, this versatile approach is extendable to membranes selective for other chiral compounds. © 2025 Elsevier B.V.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20402 - Chemical process engineering

Project

<a href="/en/project/GA23-06152S" target="_blank" >GA23-06152S: Modular approach towards chiral membranes for scalable enantioseparation of racemic drugs</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF MEMBRANE SCIENCE

ISSN

0376-7388

e-ISSN

1873-3123

Volume of the periodical

733

Issue of the periodical within the volume

September

Country of publishing house

BE - BELGIUM

Number of pages

12

Pages from-to

124376

UT code for WoS article

001525705700002

EID of the result in the Scopus database

2-s2.0-105009340385