High-Performance Enantioselective Mixed Matrix Ion-Exchange Membranes based on PVDF and EVOH Polymers with Cinchona-Derived Chiral Silica Particles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F25%3A00636975" target="_blank" >RIV/67985858:_____/25:00636975 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0376738825006891?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0376738825006891?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.memsci.2025.124376" target="_blank" >10.1016/j.memsci.2025.124376</a>
Alternative languages
Result language
angličtina
Original language name
High-Performance Enantioselective Mixed Matrix Ion-Exchange Membranes based on PVDF and EVOH Polymers with Cinchona-Derived Chiral Silica Particles
Original language description
Separation of racemic mixtures is pivotal and remains a challenging task since enantiomers exhibit identical physicochemical properties in achiral environments. Enantioselective membranes gain attention for their potential to achieve efficient and scalable chiral separation, offering a cost-effective and environmentally friendly alternative to traditional methods. Here, we present an innovative enantioselective ion-exchange mixed matrix membrane for separation of racemic acids, involving quinidine-modified 5 μm silica particles dispersed in poly(ethyleneco-vinyl alcohol) (EVOH) or poly(vinylidene fluoride) (PVDF) matrices. The separation follows a sorption-driven mechanism based on the retarded transport model, requiring periodic regeneration using methanolic ammonium acetate solution. Optimal separation conditions for N-(3,5-dinitrobenzoyl)-leucine enantiomers were found at low ionic strength with a methanol, acetic acid, and ammonium acetate solvent system. Both PVDF-based membranes, prepared via non-solvent-induced phase separation (NIPS) with a high packing ratio of 1.2:1 (particle to polymer), and EVOH-based membranes with 1:1 ratio, prepared via combined vapour-induced phase separation (VIPS) and solvent-evaporation at 50 % relative humidity, achieved ≥ 98 % enantiomeric excess (ee) after five separation stages. Fluxes averaged on (1513 ± 255) mg/m²/h (PVDF) and (1190 ± 139) mg/m²/h (EVOH) at 1 mg/mL feed concentration with ~5% stageover-stage recoveries. Pressure-driven enantioseparation using PVDF membranes required ~20 stages to achieve > 90 % ee but provided ~49 % recovery per stage. Leveraging the proven long-lasting performance of chromatographic enantioselective silica, the developed membranes enable scalable semi-continuous separation of acidic racemates. Attractively, this versatile approach is extendable to membranes selective for other chiral compounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
<a href="/en/project/GA23-06152S" target="_blank" >GA23-06152S: Modular approach towards chiral membranes for scalable enantioseparation of racemic drugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Membrane Science
ISSN
0376-7388
e-ISSN
1873-3123
Volume of the periodical
733
Issue of the periodical within the volume
SEP 2025
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
124376
UT code for WoS article
001525705700002
EID of the result in the Scopus database
2-s2.0-105009340385