Mechanistic insights into dissolution enhancement of co-spray dried meloxicam with chitosan and solubilization agent

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43933328" target="_blank" >RIV/60461373:22310/25:43933328 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41598-025-31245-1" target="_blank" >https://www.nature.com/articles/s41598-025-31245-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-31245-1" target="_blank" >10.1038/s41598-025-31245-1</a>

Result language

angličtina

Original language name

Mechanistic insights into dissolution enhancement of co-spray dried meloxicam with chitosan and solubilization agent

Original language description

This study presents a co-spray drying formulation approach to enhance the dissolution rate of meloxicam (MX), a poorly soluble model drug, by combining it with chitosan (CHIT) and sodium lauryl sulfate (SLS). Ternary formulations were prepared using both mini- and medium-scale spray dryers and compared with physical mixtures and RAW MX. In vitro dissolution testing revealed a significant increase in the release rate, with up to 80% of MX dissolved within 5 min. A comprehensive set of solid-state analytical techniques (XRPD, FTIR, and confocal Raman microscopy) revealed subtle changes in MX crystallinity and hydrogen-bonding interactions with both excipients. These findings support three key mechanisms contributing to enhanced dissolution: (i) reduced agglomeration of MX via adsorption onto the CHIT surface, (ii) improved wettability of products due to the presence of SLS, and (iii) increased matrix hydrophilicity facilitating drug-medium contact. The successful scale-up using a medium-scale spray dryer demonstrated the feasibility of this strategy for industrial application. The results highlight co-spray drying with functional excipients as a robust and scalable method for improving the biopharmaceutical performance of poorly soluble drugs. The simple co-spraying of the CHIT dispersion with the drug solution, without the need to dissolve the chitosan, is additional advantage.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10700 - Other natural sciences

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

nestránkováno

UT code for WoS article

001661349500002

EID of the result in the Scopus database

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