Effects of Roller Compaction on Dissolution of Granules and Tablets Captured in the Development of Two Real Pharmaceutical Formulations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43933631" target="_blank" >RIV/60461373:22310/25:43933631 - isvavai.cz</a>
Result on the web
<a href="https://rdcu.be/e5viv" target="_blank" >https://rdcu.be/e5viv</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1208/s12249-025-03217-1" target="_blank" >10.1208/s12249-025-03217-1</a>
Alternative languages
Result language
angličtina
Original language name
Effects of Roller Compaction on Dissolution of Granules and Tablets Captured in the Development of Two Real Pharmaceutical Formulations
Original language description
Roller compaction is often utilized as the first step to improve flow properties and homogeneity of pharmaceutical mixtures. Since the dry granulation process is less complicated than its counterparts in the industry, it is possible to perform screening experiments readily to investigate granulate quality for further operations. In this study, the aim of the investigation focused on the effect of roller compaction on the dissolution of granules and tablets of two pharmaceutical formulations that contain APIs of different biopharmaceutical classification. This study underscores the benefits of granule dissolution testing as a crucial early-stage technique for optimizing granulate quality and facilitating progression through formulation manufacturing operations. For active pharmaceutical ingredients characterized by poor dissolution properties, this approach provides valuable insights during the initial development phases. By integrating granule dissolution testing into the development process, product manufacturability can be enhanced and optimal product performance can be ensured.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30100 - Basic medicine
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AAPS PHARMSCITECH
ISSN
1530-9932
e-ISSN
1530-9932
Volume of the periodical
26
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
nestránkováno
UT code for WoS article
001564507900003
EID of the result in the Scopus database
2-s2.0-105015098773