The impact of the altered polyprotein ratios on the capsid assembly and infectivity of Mason-Pfizer monkey virus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F03%3A00008523" target="_blank" >RIV/60461373:22330/03:00008523 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The impact of the altered polyprotein ratios on the capsid assembly and infectivity of Mason-Pfizer monkey virus
Original language description
Mason-Pfizer Monkey Virus (M-PMV) belongs to the Betaretrovirus genus within the family Retroviridae and causes immunosuppressive disease of Rhesus monkey. M-PMV genome consists of four genes in the following order: 5' gag-pro-pol-env 3'. Retroviruses regulate the ratios of the primary translation products, polyprotein precursors Pr78 (Gag), Pr95 (Gag-Pro) and Pr180 (Gag-Pro-Pol), by frameshifts during translation of the individual genes in a host cell. Two frameshifts, first one at the end of gag geneand the second one at the end of pro gene, occur approximately with the efficiency of 10-20%. M-PMV structural proteins are present at the tenfold higher level than the viral enzymes. The ratio of polyprotein precursors varies in the individual retroviruses and represents a regulatory mechanism controlling relative amounts of protease and its substrates. In order to investigate the effect of the altered polyprotein precursor ratios on the efficiency of assembly, maturation and consequent
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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