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The influence of assembly conditions on effeiciency and morphology of in vitro assembled capsid-like particles formed from CA-NC of Mason-Pfirzer money virus

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012908" target="_blank" >RIV/60461373:22330/04:00012908 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The influence of assembly conditions on effeiciency and morphology of in vitro assembled capsid-like particles formed from CA-NC of Mason-Pfirzer money virus

  • Original language description

    Domains within structural polyprotein Gag of all retroviruses initiate and direct assembly of the immature viral particles. Gag forms capsid-like particles in bacteria, mammalian cells and in vitro. Several studies have shown that Gag and its deletion mutants, e.g. capsid-nucleocapsid fusion protein (CA-NC) or CA assemble in vitro into spherical, conical or tubular particles. Morphology of formed particles depends on virus type and assembly conditions. CA itself can assemble in vitro into tubular or conical structures resembling a mature core. NC facilitates Gag interactions and it is crucial for specific incorporation of genomic RNA. In previous study we have shown that Mason-Pfizer monkey virus deletion construct consisting of CA and NC fusion protein that lacks the N-terminal proline (Pro-)CA-NC assembles into spherical particles when expressed in E. coli in contrast with tubular structures formed from CA-NC under the same conditions. To evaluate the effect of nucleic acids on the a

  • Czech name

    Vliv podmínek assembly na morfologii částic tvořených z CA-NC proteinu MPMV

  • Czech description

    polyprotein Gag

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LN00A079" target="_blank" >LN00A079: Center of Integrated Genomics</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Virus Assembly Conference

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

    254

  • Publisher name

    Vermont Academy

  • Place of publication

    Vermont

  • Event location

    Vermont

  • Event date

    Jan 1, 2004

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article