Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43891958" target="_blank" >RIV/60461373:22330/11:43891958 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/11:00365232 RIV/60461373:22310/11:43891958

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants

Original language description

The interaction of cells and tissues with artificial materials designed for applications in biotechnologies and in medicine is governed by the physical and chemical properties of the material surface. There is optimal cell adhesion to moderately hydrophilic and positively charged substrates, due to the adsorption of cell adhesion-mediating molecules (e.g. vitronectin, fibronectin) in an advantageous geometrical conformation, which makes specific sites on these molecules (e.g. specific amino acid sequences) accessible to cell adhesion receptors (e.g. integrins). Highly hydrophilic surfaces prevent the adsorption of proteins, or these molecules are bound very weakly. On highly hydrophobic materials, however, proteins are adsorbed in rigid and denatured forms, hampering cell adhesion. The wettability of the material surface, particularly in synthetic polymers, can be effectively regulated by physical treatments, e.g. by irradiation with ions, plasma or UV light.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biotechnology Advances

ISSN

0734-9750

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

29

Pages from-to

739-767

UT code for WoS article

000296821900018

EID of the result in the Scopus database

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