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Chitosan derivatives as bile acid and cholesterol sorbents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43893068" target="_blank" >RIV/60461373:22330/11:43893068 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Chitosan derivatives as bile acid and cholesterol sorbents

  • Original language description

    This work is devoted to preparation of hydrophobically modified chitosans and evaluation of their sorption properties. N,N,(N)-Di(tri)methylchitosan (MC1) was prepared by the reaction of chitosan with methyl iodide; N,O-palmitoyl-chitosan (MC2) and N,N,(N)-di(tri)methyl-N,O-palmitoyl-chitosan (MC3) were prepared by the reaction of chitosan and MC1 with palmitoyl chloride, respectively. These modified chitosans were characterized by organic elemental analysis, FTIR, NMR, and DSC. The degrees of substitution were calculated from the N/C ratio and from the areas of NMR signals. The in vitro sorption of cholate and cholesterol by chitosan derivatives was studied in comparison with the original chitosan and cholestyramine, an effective synthetic sorbent ofbile acids. It was found that MC2 and MC3 are able to bind cholesterol and bile acids, respectively, and thus can be used as cholestyramine supplements to improve cholesterol metabolism.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Chitin and Chitosan

  • ISSN

    1229-4160

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    KR - KOREA, REPUBLIC OF

  • Number of pages

    9

  • Pages from-to

    262-270

  • UT code for WoS article

  • EID of the result in the Scopus database