Cholesterol and fat lowering with hydrophobic polysaccharide derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00457794" target="_blank" >RIV/67985904:_____/15:00457794 - isvavai.cz</a>
Alternative codes found
RIV/00027014:_____/15:#0002175
Result on the web
<a href="http://dx.doi.org/10.1016/j.carbpol.2014.05.009" target="_blank" >http://dx.doi.org/10.1016/j.carbpol.2014.05.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2014.05.009" target="_blank" >10.1016/j.carbpol.2014.05.009</a>

Result language
angličtina
Original language name
Cholesterol and fat lowering with hydrophobic polysaccharide derivatives
Original language description
Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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