Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of alpha- and beta-adrenergic signalling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43894333" target="_blank" >RIV/60461373:22330/12:43894333 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/12:00056333

Result on the web

<a href="http://dx.doi.org/10.1258/ebm.2011.011189" target="_blank" >http://dx.doi.org/10.1258/ebm.2011.011189</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1258/ebm.2011.011189" target="_blank" >10.1258/ebm.2011.011189</a>

Result language

angličtina

Original language name

Epinephrine-dependent control of glucose metabolism in white adipose tissue: the role of alpha- and beta-adrenergic signalling

Original language description

Epinephrine controls many important and sometimes opposite processes. This pleiotropic effect is achieved via coupling to different receptor/effector systems. In epididymal white adipose tissue (EWAT) of Wistar rats, we showed that epinephrine stimulatedprotein kinase B (PKB) phosphorylation on Ser(473). Epinephrine further increased the glucose incorporation into glyceride-glycerol without decreasing glucose availability for other metabolic pathways (i.e. lactate production). Wortmannin (phosphatidylinositol 3-kinase inhibitor) treatment significantly decreased glucose incorporation into glyceride-glycerol and elevated the epinephrine-induced release of free fatty acids (FFA) from the adipose tissue without any change in the intensity of lipolysis measured as glycerol release. Using specific cyclic adenosine monophosphate (cAMP) analogs we demonstrated that cAMP-protein kinase A (PKA) signalling resulted in a strong PKB dephosphorylation and significantly lowered the glucose availabi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/NS9696" target="_blank" >NS9696: Mechanisms and consequences of the accumulation of lipids in liver associated with metabolic syndrome - the possibilities of nutritional and pharmacological intervention</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental biology and medicine

ISSN

1535-3702

e-ISSN

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Volume of the periodical

237

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

211-218

UT code for WoS article

000301914700012

EID of the result in the Scopus database

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