Preparation and characterization of lipid nanoparticles containing lipophilic actives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F14%3A43897693" target="_blank" >RIV/60461373:22330/14:43897693 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/14:43897693 RIV/60461373:22340/14:43897693
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Preparation and characterization of lipid nanoparticles containing lipophilic actives
Original language description
The aim of this study was to prepare two types of colloidal systems, liposomes and lipid nanoparticles, containing commercially available ceramide VI. Ceramides are the main components of the stratum corneum, the physical and mechanical barrier of the skin. Ceramide supplementation is on approach to the treatment of a disrupted skin in diseases such as atopic dermatitis, ichthyosis, psoriasis and others. Different amounts of cermide VI were loaded into the colloidal nanoparticles. High performance thinlayer chromatography was used to confirm the amount of the incorporated ceramide VI. Size and zeta potential of the particles were determined by dynamic light scattering method. The particles were visualized by transmission electron microscopy. Our results suggest that colloidal nanoparticles are suitable drug delivery systems to incorporate ceramide VI. Both, liposomes and lipid nanoparticles, have shown a spherical shpae, an average size below the 100nm and a low polydispersity index.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-23891S" target="_blank" >GA13-23891S: Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering
ISBN
978-80-89475-13-1
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
817-822
Publisher name
Slovak Society of Chemical Engineering
Place of publication
Bratislava
Event location
Tatranské Matliare
Event date
May 26, 2014
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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