Determination of Impurities in Bioproduced Succinic Acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F15%3A43899340" target="_blank" >RIV/60461373:22330/15:43899340 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/15:43899340
Result on the web
<a href="http://dx.doi.org/10.4172/2157-7064.1000264" target="_blank" >http://dx.doi.org/10.4172/2157-7064.1000264</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4172/2157-7064.1000264" target="_blank" >10.4172/2157-7064.1000264</a>

Result language
angličtina
Original language name
Determination of Impurities in Bioproduced Succinic Acid
Original language description
At present, significant research resources are directed towards development of renewable products for replacing petrochemicals such as succinic acid. The critical component of this research is the identification of impurities which have a detrimental impact on further processing of succinic acid. We have adapted derivatization with gas chromatography - mass spectrometry to identify and quantify more than 120 impurities in several succinic acid samples. This study focused on petroleum based succinic acidas well as bio-based samples that use a modified E. coli strain for fermentation. To enable an accurate quantification of both the target product and common impurities, we evaluated the acetonitrile extraction efficiency as an alternative to direct derivatization, and then compared several derivatization agents for trimethylsilylation. A prior acetonitrile extraction was shown to be essential to detect impurities in trace concentrations. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA)
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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