Impact of Air Pollution to Genome of Newborns

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F16%3A43903021" target="_blank" >RIV/60461373:22330/16:43903021 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/16:00472879 RIV/60076658:12110/16:43891151
Result on the web
<a href="http://apps.szu.cz/svi/cejph/archiv/2016-sup-06-full.pdf" target="_blank" >http://apps.szu.cz/svi/cejph/archiv/2016-sup-06-full.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21101/cejph.a4536" target="_blank" >10.21101/cejph.a4536</a>

Result language
angličtina
Original language name
Impact of Air Pollution to Genome of Newborns
Original language description
The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Project
<a href="/en/project/GA13-13458S" target="_blank" >GA13-13458S: Impact of air pollution to genome of newborns</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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