Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F17%3A43914451" target="_blank" >RIV/60461373:22330/17:43914451 - isvavai.cz</a>
Result on the web
<a href="http://www.dl.begellhouse.com/journals/708ae68d64b17c52,305c54e9703680c8,1cb5fe9d1c31da44.html" target="_blank" >http://www.dl.begellhouse.com/journals/708ae68d64b17c52,305c54e9703680c8,1cb5fe9d1c31da44.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1615/IntJMedMushrooms.2017024413" target="_blank" >10.1615/IntJMedMushrooms.2017024413</a>
Alternative languages
Result language
angličtina
Original language name
Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory activity
Original language description
Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly beta-glucans, mannogalactans, and glycogen (e.g., alpha-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more beta-(1 -> 3)-glucans than beta-(1 -> 3),(1 -> 6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10612 - Mycology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Medicinal Mushrooms
ISSN
1521-9437
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
10
Country of publishing house
SI - SLOVENIA
Number of pages
14
Pages from-to
879-892
UT code for WoS article
000417065300003
EID of the result in the Scopus database
2-s2.0-85037060097