Biologically Active Extracts from Calendula officinalis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F19%3A43918413" target="_blank" >RIV/60461373:22330/19:43918413 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22810/19:43918413

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Biologically Active Extracts from Calendula officinalis

Original language description

The aim of this work was to compare water and organic extracts, infusions and tinctures from flowers and leaves of Calendula officinalis in terms of their biological activity and composition. The purpose of work was investigation whether the leaves and stems are really the waste or they contain interesting substances which could be utilized. Antimicrobial, antifungal, antioxidant and anti-inflammatory activities were studied. Then the ability to inhibit collagenase was studied as well. Cytotoxicity was tested for all the samples on mammalian cell lines. To determine the composition of extracts, infusions and tinctures phytochemical analysis (the set of colour reactions for detection of groups of biologically active compounds) was carried out and shown that samples from flowers and leaves contain the same groups of biologically active substances (proteins and amino acids, reducing sugars, flavonoids, saponins, phenolics, terpenoids, steroids, glycosides). The antimicrobial activity of tested samples was proved, where the most sensitive bacterium was Micrococcus luteus and the most sensitive yeast was Geotrichum candidum. The study of anti - collagenase activity has shown that the enzymatic reaction of collagenase was affected by all tested samples and their effect was concentration dependent. Cytotoxicity of water and methanol extracts at cell lines HEK 293T and HepG2 was observed. Cells HepG2 were more sensitive than cells HEK 293T. Using cell line RAW 264.7 anti-inflammatory activity of all samples was observed. Tincture of leaves was the most effective.

Czech name

—

Czech description

—

Type

C - Chapter in a specialist book

CEP classification

—

OECD FORD branch

20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation

Project

<a href="/en/project/TE01020080" target="_blank" >TE01020080: Biorefinery Research Centre of Competence</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

BIOREFINING in the 21st Century

ISBN

978-80-86186-02-3

Number of pages of the result

3

Pages from-to

64-66

Number of pages of the book

109

Publisher name

Institute of Chemical Process Fundamentals of the CAS, v. v. i.

Place of publication

Prague

UT code for WoS chapter

—