Cytotoxic, anti-cancer, and anti-microbial effects of different extracts obtained from Artemisia rupestris

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875741" target="_blank" >RIV/62157124:16370/17:43875741 - isvavai.cz</a>

Result on the web

<a href="http://www.prolekare.cz/en/czech-slovak-pharmacy-article/cytotoxic-anti-cancer-and-anti-microbial-effects-of-different-extracts-obtained-from-artemisia-rupestris-61009" target="_blank" >http://www.prolekare.cz/en/czech-slovak-pharmacy-article/cytotoxic-anti-cancer-and-anti-microbial-effects-of-different-extracts-obtained-from-artemisia-rupestris-61009</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Cytotoxic, anti-cancer, and anti-microbial effects of different extracts obtained from Artemisia rupestris

Original language description

Artemisia rupestris is a part of traditional Kazakh folk medicine. Extracts obtained from this plant are used to treat various diseases, including cancer. This study evaluates the anti-microbial, cytotoxic, and anti-cancer effects of different extracts of the plant. Different extraction techniques were used and the resultant activities were compared. Extracts of A. rupestris were prepared from the flowers plus the leaves and from the stems. The antimicrobial activity against Candida albicans and Staphylococcus aureus was quantified. Cell lines L1210 and THP-1 were used to evaluate the cytotoxic potential of these extracts in vitro. The anti-cancer effect was tested using L1210-induced tumorgenesis in mouse model. The aqueous extract of stems was the most active against C. albicans, whereas the methanolic extract of flowers plus leaves especially inhibited the growth of S. aureus. The aqueous extracts were found to be non-cytotoxic for both cell lines, whereas the lipophilic extracts showed cytotoxic effects. The extract obtained from flowers plus leaves was more cytotoxic than that from stems. The tested extracts showed no anti-cancer potential. The results obtained testify to the relatively safe consumption of aqueous extracts of A. rupestris, but lipophilic extracts showed toxic effects and their consumption should be considered more carefully.

Czech name

—

Czech description

—

Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

—

Volume of the periodical

66

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

15-22

UT code for WoS article

—

EID of the result in the Scopus database

—