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Skin film lipids, their characteristic and biological activity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F19%3A43919032" target="_blank" >RIV/60461373:22330/19:43919032 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    čeština

  • Original language name

    Lipidy kožního filmu, jejich charakteristika a biologická aktivita

  • Original language description

    The work is focused on detailed characterization and representation of fatty acids in sebum of adults and children. Several functional derivatives have been prepared by sapienic acid esterification: sapienic acid esters of fatty alcohols, sapienic acid glyceryl ester and disapienoyl phosphatidylcholine. The prepared substances were tested for their antimicrobial activity against microorganisms present on human skin (Staphylococcus epidermidis), potential pathogens of human skin (Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Candida albicans, Aspergilus niger) and microorganisms associated with various skin diseases (Propionibacterium acnes, Malassezia furfur). Sapienic acid acted relatively well against all microorganisms, with lower inhibitory activity against gram-negative batteries. Sapienic acid glyceryl ester and disapianoyl phosphatidylcholine showed high potency against Pr. acnes and C. albicans, low potency against gram-positive bacteria, and minimal inhibitory activity against gram-negative bacteria. Sapienic esters of C12:0 - C20:0 alcohols had moderate activity against Pr. acnes and C. albicans, low potency against gram-positive bacteria, and minimal inhibitory activity against gram-negative bacteria. The antimicrobial effect of the test compounds is related to their polarity and cell wall composition of selected microorganisms.

  • Czech name

    Lipidy kožního filmu, jejich charakteristika a biologická aktivita

  • Czech description

    The work is focused on detailed characterization and representation of fatty acids in sebum of adults and children. Several functional derivatives have been prepared by sapienic acid esterification: sapienic acid esters of fatty alcohols, sapienic acid glyceryl ester and disapienoyl phosphatidylcholine. The prepared substances were tested for their antimicrobial activity against microorganisms present on human skin (Staphylococcus epidermidis), potential pathogens of human skin (Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Candida albicans, Aspergilus niger) and microorganisms associated with various skin diseases (Propionibacterium acnes, Malassezia furfur). Sapienic acid acted relatively well against all microorganisms, with lower inhibitory activity against gram-negative batteries. Sapienic acid glyceryl ester and disapianoyl phosphatidylcholine showed high potency against Pr. acnes and C. albicans, low potency against gram-positive bacteria, and minimal inhibitory activity against gram-negative bacteria. Sapienic esters of C12:0 - C20:0 alcohols had moderate activity against Pr. acnes and C. albicans, low potency against gram-positive bacteria, and minimal inhibitory activity against gram-negative bacteria. The antimicrobial effect of the test compounds is related to their polarity and cell wall composition of selected microorganisms.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    21101 - Food and beverages

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Sborník přednášek z mezinárodní kosmetologické konfernce Luhačovice 2019

  • ISBN

    978-80-904679-3-4

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    68-71

  • Publisher name

    Kosmetologická společnost České republiky

  • Place of publication

    Praha

  • Event location

    Luhačovice

  • Event date

    Oct 2, 2019

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article