Cannabis Metabolomic Data Processing: Challenges to be Addressed

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43922646" target="_blank" >RIV/60461373:22330/21:43922646 - isvavai.cz</a>
Result on the web
<a href="https://www.chromatographyonline.com/view/cannabis-metabolomic-data-processing-challenges-to-be-addressed" target="_blank" >https://www.chromatographyonline.com/view/cannabis-metabolomic-data-processing-challenges-to-be-addressed</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cannabis Metabolomic Data Processing: Challenges to be Addressed
Original language description
The interest in cannabis products is growing exponentially, because they are expected to provide a number of beneficial and therapeutic effects. Cannabis plants contain a number of unique biologically active secondary metabolites, with their pattern largely dependent not only on a respective variety or chemotype but also on several other factors. This article presents the challenges that arise during cannabis metabolomics analysis using ultrahigh-performance reversed‑phase liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC–reversed‑phase–HRMS/MS). For this purpose, ethanolic extracts of two cannabis varieties were measured twice within one month and the obtained datasets were chemometrically analyzed with respect to the analysis date. Rather surprisingly, the effect of time variability was observed at the level of expression of relative abundance of features as well as in multivariate models, where not only variety clustering but also time-dependent clustering occurred. The data handling workflow, within time variability can be revealed and removed by advanced normalization method, is described.
Czech name
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Czech description
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Project
<a href="/en/project/TN01000048" target="_blank" >TN01000048: Biorefining as circulation technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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