Antimicrobial and antivirulence activity of pterostilbene, methoxylated derivative of resveratrol

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F21%3A43925611" target="_blank" >RIV/60461373:22330/21:43925611 - isvavai.cz</a>
Result on the web
<a href="https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf" target="_blank" >https://www.icct.cz/cs/Amca-ICCT/media/content/2021/proceedings/ICCT2021-Proceedings.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Antimicrobial and antivirulence activity of pterostilbene, methoxylated derivative of resveratrol
Original language description
With and increased incidence of antibiotic resistance among pathogenic bacteria and fungi, there is a great pressure on novel drug development. The research is now focused on drugs with potential antivirulence activity rather than traditional antimicrobial substances due to decreased selective pressure on treated pathogen and lower probability of resistance development. The presented study observed antimicrobial and antibiofilm effect of natural compound pterostilbene compared to traditional macrolide antibiotic – erythromycin on clinically relevant staphylococci.Pterostilbene was effective against both suspension growth and biofilm formation in contrast to erythromycin. Pterostilbene was found to have bactericidal action on Staphylococcus aureus and in combination (49 mg/l) with antibiotic it enhanced erythromycin (5 mg/l) activity and decreased biofilm formation by more than 80% in all studied strains of Staphylococcus epidermidis. Studied stilbene was proved to be a suitable complement of otherwise ineffective antibiotics in treatment of infectious diseases caused by representatives of genus Staphylococcus.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 8th International Conference on Chemical Technology
ISBN
978-80-88307-08-2
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
277-280
Publisher name
Czech Society of Industrial Chemistry
Place of publication
Prague
Event location
Praha
Event date
May 3, 2021
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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